heparin sodium injection

Heparin SodiumInjection, is a sterile, nonpyrogenic solution of heparin sodium (derived from porcine intestinal mucosa) in water for injection. The solution containsno bacteriostat, antimicrobial agent oradded buffer and is intended for use only as a single-dose injection. Whensmaller doses are required, the unused portion should be discarded.

Heparin sodium in the ADD-Vantage™ systemis intended for intravenous administration only after dilution.

HeparinSodium, is a heterogenous group of straight-chain anionic mucopolysaccharides,called glycosamino-glycans having anticoagulant properties.Although others may be present, the main sugars occurring in heparin are: (1)α-L-iduronic acid 2-sulfate, (2)2-deoxy-2-sulfamino-α-D-glucose-6-sulfate, (3) β-D-glucuronic acid, (4)2-acetamido-2-deoxy-α-D-glucose, and (5) α-L-iduronic acid. These sugars arepresent in decreasing amounts, usually in the order (2) > (1) > (4) >(3) > (5), and are joined by glycosidic linkages, forming polymers ofvarying sizes. Heparin is strongly acidic because of its content of covalentlylinked sulfate and carboxylic acid groups. In heparin sodium, the acidicprotons of the sulfate units are partially replaced by sodium ions. The potencyis determined by a biological assay using a USP reference standard based onunits of heparin activity per milligram.